Well...My Accutane hell experience has officially started.
I'm dreading this ugly ducky to swan phase.
The dry lips/skin....But it's only four months...
These will be some character building dry skin having/ peeling like a snake/
hide in the house/go to school months.
Then in the spring....no more tinted moisturizer or insecurity about my skin..HOOOORRAAAYYY!!
It amazes me how many people have taken accutane, people I never would have thought needed to (cause their skin is flawless).
Even the pharmacist I talked to tonight took it when she was younger (she had beautiful skin).
Long story short, I'm excited to see the long term result.
I feel like every part of me is a work in progress and I hope that feeling never stops because if it does that means I've stopped wanting to better myself and learn.
I hope I'm like the old 80 year old ladies still in school just cause they want to learn :)!!
The science of accutane....
And yes rarely people can have awful side effects but it's very rare, like you getting snacked on by a shark while playing in his backyard.
My opinion on accutane is this....I've struggled with acne on and off since seventh grade. Antibiotics for years to come or accutane for 4months. I chose the lesser of two evils, sometimes that's the only option. We shall see how my gamble pays out. Go big or go home!! ;).
As far as my neck goes....It's still to be determined...still going to PT.
I'm dreading this ugly ducky to swan phase.
The dry lips/skin....But it's only four months...
These will be some character building dry skin having/ peeling like a snake/
hide in the house/go to school months.
Then in the spring....no more tinted moisturizer or insecurity about my skin..HOOOORRAAAYYY!!
It amazes me how many people have taken accutane, people I never would have thought needed to (cause their skin is flawless).
Even the pharmacist I talked to tonight took it when she was younger (she had beautiful skin).
Long story short, I'm excited to see the long term result.
I feel like every part of me is a work in progress and I hope that feeling never stops because if it does that means I've stopped wanting to better myself and learn.
I hope I'm like the old 80 year old ladies still in school just cause they want to learn :)!!
The science of accutane....
Isotretinoin's exact mechanism of action is unknown but several studies have shown that isotretinoin induces apoptosis (cell death) in various cells in the body such as cells in meibomian glands,[40][41] hypothalamic cells,[88] hippocampus cells[82][83] and important for treatment of acne, in sebaceous gland cells.[42][43]
One study found that isotretinoin significantly changed the expression of hundreds of genes in skin after 8 weeks of therapy.[89]
Isotretinoin is also one of several drugs discussed in a recent study[90] examining epigenetic side effects (for example DNA methylation) of common pharmaceuticals that leads to silencing of genes.[citation needed]
One study suggests the drug amplifies production of neutrophil-gelatinase-associated lipocalin (NGAL) in the skin, which has been shown to reduce sebum production by inducing apoptosis in sebaceous gland cells, while exhibiting an antimicrobial effect onPropionibacterium acnes.[91][92][93] The drug decreases the size and sebum output of the sebaceous glands.[94] Isotretinoin's combined impact on several of acne's contributory factors distinguishes it from alternative remedies, such as antibiotics, and accounts for its greater efficacy in severe, nodulocystic cases.[citation needed]
The effect on sebum production can be temporary[95] and remission of the disease can be "complete and prolonged."[94][96][97]
Isotretinoin has been speculated to down-regulate the telomerase enzyme and hTERT, inhibiting "cellular immortalization andtumorigenesis."[98]
Isotretinoin has also been proved, according to a 2007 study, to inhibit the action of the metalloprotease MMP-9 (gelatinase) insebum, without any influence in the action of TIMP1 and TIMP2 (tissue inhibitors of metalloproteases).[99] It is already known that metalloprotases play an important role in the pathogenesis of acne,[100] thus the inhibition of their action by isotretinoin is an additional mechanism of action that contributes to the efficacy of Isotretinoin.
And yes rarely people can have awful side effects but it's very rare, like you getting snacked on by a shark while playing in his backyard.
My opinion on accutane is this....I've struggled with acne on and off since seventh grade. Antibiotics for years to come or accutane for 4months. I chose the lesser of two evils, sometimes that's the only option. We shall see how my gamble pays out. Go big or go home!! ;).
As far as my neck goes....It's still to be determined...still going to PT.
